4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

Base Information

Chemical Name:4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine
CAS No.:1017277-88-1
Molecular Formula:C₁₉H₃₂ClN₃OS
Molecular Weight:386.002
Hs Code.:

Synonyms:4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

Chemical Property:

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Technology Process of 4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

There total 1 articles about 4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 869478-41-1
4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

: 1017277-88-1
4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2007.11.128

Reference yield:

: 1017277-88-1
4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

: 199679-74-8
(R)-2-methyl-3-(4-chlorophenyl)propionic acid

: N-((1S)-{2-[4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]-1-piperazinyl}-5-chlorophenyl]-3-methylbutyl)-(S)-tert-butanesulfinamide

Guidance literature:: 4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine; (R)-2-methyl-3-(4-chlorophenyl)propionic acid; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; Further stages.;
DOI:10.1021/jm701137s

Reference yield:

: 1017277-88-1
4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

: trans-2-(4-chlorophenyl)tetrahydrofuran-3-carboxylic acid

: C₃₀H₄₁Cl₂N₃O₃S

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2007.11.128