methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

Base Information

Chemical Name:methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate
CAS No.:1428154-99-7
Molecular Formula:C₁₄H₁₀F₃NO₃
Molecular Weight:297.234
Hs Code.:

Synonyms:methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

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Chemical Property of methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

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Technology Process of methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

There total 3 articles about methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 10128-91-3
methyl 2-hydroxynicotinate

: 401-81-0
m-trifluoromethylphenyl iodide

: 1428154-99-7
methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: With caesium carbonate; ethyl 2-oxocyclohexane carboxylate; copper(I) bromide; In dimethyl sulfoxide; at 60 ℃; for 18h; Sealed tube;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 609-71-2
2-hydroxy-3-carboxypyridine

: 1428154-99-7
methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dichloromethane / 4 h / 75 °C

2: 12 h / 20 °C

3: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 60 °C / Sealed tube

With thionyl chloride; caesium carbonate; ethyl 2-oxocyclohexane carboxylate; copper(I) bromide; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.06.005

Reference yield:

: 28369-76-8
2-hydroxynicotinic acid chloride

: 1428154-99-7
methyl 2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 12 h / 20 °C

2: ethyl 2-oxocyclohexane carboxylate; caesium carbonate; copper(I) bromide / dimethyl sulfoxide / 18 h / 60 °C / Sealed tube

With caesium carbonate; ethyl 2-oxocyclohexane carboxylate; copper(I) bromide; In dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.06.005