N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline

Base Information

• Chemical Name: N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline
• CAS No.: 1281850-66-5
• Molecular Formula: C₂₂H₃₁NO
• Molecular Weight: 325.494
• Mol file: 1281850-66-5.mol

Synonyms:N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline

Chemical Property of N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline

There total 3 articles about N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-bromo-hexane (111-25-1) + N-(4-methoxyphenyl)-1-(m-tolyl)ethan-1-imine (434951-37-8) + N-(1-(3-chlorophenyl)ethylidene)-4-methoxybenzenamine (960009-48-7) → N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline (1281850-66-5) + N-{1-(5-chloro-2-n-hexylphenyl)ethyl}-4-methoxyaniline (1281850-67-6)

Guidance literature:

1-bromo-hexane; N-(4-methoxyphenyl)-1-(m-tolyl)ethan-1-imine; N-(1-(3-chlorophenyl)ethylidene)-4-methoxybenzenamine; With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1-Adamantanecarboxylic acid; potassium carbonate; In m-xylene; at 120 ℃; for 20h; Inert atmosphere;

With sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; methanol; m-xylene; at 20 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol200366n

Reference yield:

C22H29NO → N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline (1281850-66-5)

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; methanol; m-xylene; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol200366n

Reference yield:

1-bromo-hexane (111-25-1) + N-(4-methoxyphenyl)-1-(m-tolyl)ethan-1-imine (434951-37-8) → N-{1-(2-n-hexyl-5-methylphenyl)ethyl}-4-methoxyaniline (1281850-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1-Adamantanecarboxylic acid; potassium carbonate / m-xylene / 20 h / 120 °C / Inert atmosphere

2: sodium cyanoborohydride; zinc(II) chloride / tetrahydrofuran; methanol; m-xylene / 16 h / 20 °C / Inert atmosphere

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; 1-Adamantanecarboxylic acid; sodium cyanoborohydride; potassium carbonate; zinc(II) chloride; In tetrahydrofuran; methanol; m-xylene;

DOI:10.1021/ol200366n

upstream raw materials:

1-bromo-hexane

N-(4-methoxyphenyl)-1-(m-tolyl)ethan-1-imine

N-(1-(3-chlorophenyl)ethylidene)-4-methoxybenzenamine