(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

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Chemical Name:(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one
CAS No.:1445973-93-2
Molecular Formula:C₂₈H₂₃N₃O₇S
Molecular Weight:545.573
Hs Code.:

Synonyms:(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

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Chemical Property of (E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

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Technology Process of (E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

There total 5 articles about (E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1445973-86-3
(E)-1-(2-(2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1H-indol-3-yl)ethanone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1445973-93-2
(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

Guidance literature:: With guanidineacetic acid; at 100 ℃; for 3h; Inert atmosphere;
DOI:10.1021/ol4015738

Reference yield:

: 1445973-83-0
C₃₅H₂₈NO₃PS

: 1445973-93-2
(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 6 h / Reflux; Inert atmosphere

2: guanidineacetic acid / 3 h / 100 °C / Inert atmosphere

With guanidineacetic acid; In 1,2-dichloro-ethane;
DOI:10.1021/ol4015738

Reference yield:

: 113685-33-9
3-acetyl-2-methyl-1-(phenylsulfonyl)indole

: 1445973-93-2
(E)-3-(dimethylamino)-1-(2-((E)-2-(6-nitrobenzo[d][1,3]dioxol-5-yl)vinyl)-1-(phenylsulfonyl)-1Hindol-3-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / Reflux; Inert atmosphere

2.1: tetrahydrofuran / 2 h / Reflux; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 6 h / Reflux; Inert atmosphere

4.1: guanidineacetic acid / 3 h / 100 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); guanidineacetic acid; In tetrahydrofuran; tetrachloromethane; 1,2-dichloro-ethane;
DOI:10.1021/ol4015738