(S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid

Base Information

• Chemical Name: (S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid
• CAS No.: 950672-52-3
• Molecular Formula: C₁₃H₁₄F₃NO₃S
• Molecular Weight: 321.32
• Mol file: 950672-52-3.mol

Synonyms:(S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid

Chemical Property of (S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid

There total 1 articles about (S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

(RS)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid (950672-51-2) → (S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid (950672-52-3) + (R)-S-benzyl-α-methylcysteine (249749-42-6,52616-59-8)

Guidance literature:

(RS)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid; With water; sodium carbonate; cobalt(II) chloride; L-amino acid acylase; at 45 ℃; for 30h; pH=~ 7.5 - 8; Resolution of racemate; Enzymatic reaction; borate buffer;

With acetic acid; In water; at 20 ℃; pH=7;

With hydrogenchloride; In water; at 20 ℃; Purification / work up;

Reference yield: 98.0%

(S)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid (950672-52-3) → (S)-2-amino-3-benzylsulfanyl-2-methyl-propionic acid (52616-59-8)

Guidance literature:

With methanol; potassium hydroxide; water; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

(RS)-3-benzylsulfanyl-2-methyl-2-(2,2,2-trifluoro-acetylamino)-propionic acid

Downstream raw materials:

(S)-2-amino-3-benzylsulfanyl-2-methyl-propionic acid