5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

Base Information

Chemical Name:5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile
CAS No.:1426800-59-0
Molecular Formula:C₂₁H₁₃F₃N₆O
Molecular Weight:422.369
Hs Code.:

Synonyms:5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

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Chemical Property of 5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

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Technology Process of 5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

There total 8 articles about 5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426800-30-7
5-(4-cyanophenyl)-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid amide

: 1426800-59-0
5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 674290-07-4
4-(4-cyanophenyl)-6-methyl-2-thioxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester

: 1426800-59-0
5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: urea hydrogen peroxide adduct / ethanol / 5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C

3.1: ethanol / 1 h / 150 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 5 h / -78 - 0 °C / Inert atmosphere

4.2: pH 1 / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

5.2: 16 h / 60 °C

6.1: Burgess Reagent / tetrahydrofuran / 0.5 h / 20 °C

With Burgess Reagent; urea hydrogen peroxide adduct; boron tribromide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1426800-46-5
5-(4-cyanophenyl)-7-methyl-3-oxo-8-[3-(trifluoromethyl)phenyl]-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

: 1426800-59-0
5-(4-cyano-phenyl)-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 5 h / -78 - 0 °C / Inert atmosphere

1.2: pH 1 / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

2.2: 16 h / 60 °C

3.1: Burgess Reagent / tetrahydrofuran / 0.5 h / 20 °C

With Burgess Reagent; boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;