methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

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Chemical Name:methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt
CAS No.:1394136-30-1
Molecular Formula:C₃H₉N*C₁₃H₈F₄N₂O₄
Molecular Weight:391.322
Hs Code.:

Synonyms:methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

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Chemical Property of methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

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Technology Process of methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

There total 1 articles about methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 371-14-2
4-fluorophenylhydrazine

: dimethyl 2-<(1-methylethyl)amino>-3-(trifluoroacetyl)-2-butenedioate

: 1394136-30-1
methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

Guidance literature:: In diethyl ether; for 10h;
DOI:10.1016/j.ejmech.2012.04.020

Reference yield: 88.0%

: 1394136-30-1
methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

: 1394136-29-8
methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate

Guidance literature:: With hydrogenchloride; In water; at 0 ℃; for 1h; pH=2 - 3;
DOI:10.1016/j.ejmech.2012.04.020

Reference yield:

: 1394136-30-1
methyl 1,6-dihydro-5-hydroxy-6-oxo-1-(4-fluorophenyl)-3-(trifluoromethyl)-4-pyridazinecarboxylate isopropylamine salt

: 1394136-33-4
N-(4-fluorobenzyl)-1-(4-fluorophenyl)-5-hydroxy-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxamide

: 1394136-34-5
N-(4-fluorobenzyl)-5-(4-fluorobenzylamino)-1-(4-fluorophenyl)-6-oxo-3-(trifluoromethyl)-1,6-dihydropyridazine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 1 h / 0 °C / pH 2 - 3

2.1: potassium carbonate / acetone / 0.5 h

2.2: 36 h / Reflux

3.1: 11 h / 20 °C / Reflux

With hydrogenchloride; potassium carbonate; In water; acetone;
DOI:10.1016/j.ejmech.2012.04.020