Chemical Property of Misonidazole
Chemical Property:
- Vapor Pressure:1.83E-08mmHg at 25°C
- Refractive Index:1.6500 (estimate)
- Boiling Point:438.5°C at 760 mmHg
- Flash Point:219°C
- PSA：93.10000
- Density:1.43g/cm3
- LogP:0.32180
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
- XLogP3:-0.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:201.07495584
- Heavy Atom Count:14
- Complexity:196
- Purity/Quality:
-
99% *data from raw suppliers
Misonidazole *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COCC(CN1C=CN=C1[N+](=O)[O-])O
- Recent EU Clinical Trials:Do Selective Radiation Dose Escalation and Tumor Hypoxia Status Impact the Locoregional Tumor Control after Radiochemotherapy of Head & Neck Tumors?
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Description
Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.
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Uses
Antiprotozoal (Trichomonas). Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
