methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Base Information

Chemical Name:methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate
CAS No.:1609122-82-8
Molecular Formula:C₂₅H₂₈F₂N₂O₅S
Molecular Weight:506.571
Hs Code.:

methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Synonyms:methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Chemical Property of methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

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Technology Process of methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

There total 17 articles about methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609122-73-7
methyl 5-amino-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-82-8
methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 72 h / 20 °C

2: potassium carbonate; water / methanol / 1 h / 45 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

With pyridine; water; sodium tris(acetoxy)borohydride; potassium carbonate; In methanol; dichloromethane;

Reference yield:

: 1609122-78-2
methyl 2-(2,2-dimethylpropionylamino)-4-fluoro-6-hydroxybenzoate

: 1609122-82-8
methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / toluene; acetone / 20 h / Reflux

2.1: bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) / toluene / 3 h / 85 °C

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water; dichloromethane / 2 h / 50 °C

4.1: sulfuric acid; methanol / 24 h / Reflux

4.2: 24 h / Reflux

5.1: zinc; ammonium chloride / 20 h / 85 °C / Inert atmosphere

6.1: pyridine / dichloromethane / 72 h / 20 °C

7.1: potassium carbonate; water / methanol / 1 h / 45 °C

8.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

With pyridine; methanol; sulfuric acid; bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I); N-benzyl-N,N,N-triethylammonium chloride; water; sodium tris(acetoxy)borohydride; potassium carbonate; ammonium chloride; sodium hydroxide; zinc; In methanol; dichloromethane; water; acetone; toluene;

Reference yield:

: 1609122-75-9
methyl 1,1-dibromo-5-(2,2-dimethylpropionylamino)-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1609122-82-8
methyl 5-[2-((R)-1-ethylpyrrolidin-3-ylmethyl)-4-fluorobenzene-sulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; methanol / 24 h / Reflux

1.2: 24 h / Reflux

2.1: zinc; ammonium chloride / 20 h / 85 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 72 h / 20 °C

4.1: potassium carbonate; water / methanol / 1 h / 45 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

With pyridine; methanol; sulfuric acid; water; sodium tris(acetoxy)borohydride; potassium carbonate; ammonium chloride; zinc; In methanol; dichloromethane;