methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Base Information

Chemical Name:methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate
CAS No.:121653-75-6
Molecular Formula:C₁₆H₁₇FN₂O₆
Molecular Weight:352.319
Hs Code.:

Synonyms:methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

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Chemical Property of methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

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Technology Process of methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

There total 3 articles about methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 121653-75-6
methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 5.07 g / benzene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

3: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In dichloromethane; benzene;
DOI:10.1021/jm00128a032

Reference yield:

: 121653-72-3
(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

: 121653-75-6
methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In dichloromethane;
DOI:10.1021/jm00128a032

Reference yield:

: 51-21-8
5-fluorouracil

: 121653-73-4
methyl chloro<2-(phenylmethoxy)ethoxy>acetate

: 121653-75-6
methyl 5-fluoro-3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h;
DOI:10.1021/jm00128a032