1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

Base Information

Chemical Name:1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester
CAS No.:164160-64-9
Molecular Formula:C₃₉H₅₈N₂O₃
Molecular Weight:602.901
Hs Code.:

Synonyms:1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

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Chemical Property of 1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

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Technology Process of 1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

There total 7 articles about 1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 80-48-8
methyl p-toluene sulfonate

: 164160-61-6
3-[1-(3-Phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

: 164160-64-9
1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In diethyl ether; dichloromethane; Ambient temperature;
DOI:10.1002/ardp.19963290803

Reference yield:

: 3770-50-1,117770-52-2
2-carbethoxyindole

: 164160-64-9
1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / polyphosphoric acid, TFAA / CH₂Cl₂ / 5 h / Ambient temperature

2: 33 percent / NH₂OH*HCl, pyridine / ethanol / 2 h / Heating

3: NaOAc, Zn / acetic acid / 0.75 h / Ambient temperature

4: NEt₃, 4-dimethylaminopyridine / CHCl₃ / Ambient temperature

5: 79 percent / Bu₄NBr, NaOH / diethyl ether; CH₂Cl₂ / Ambient temperature

With pyridine; dmap; sodium hydroxide; PPA; hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium acetate; triethylamine; trifluoroacetic anhydride; zinc; In diethyl ether; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1002/ardp.19963290803

Reference yield:

: 57-11-4
stearic acid

: 164160-64-9
1-Methyl-3-[1-(3-phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / polyphosphoric acid, TFAA / CH₂Cl₂ / 5 h / Ambient temperature

2: 33 percent / NH₂OH*HCl, pyridine / ethanol / 2 h / Heating

3: NaOAc, Zn / acetic acid / 0.75 h / Ambient temperature

4: NEt₃, 4-dimethylaminopyridine / CHCl₃ / Ambient temperature

5: 79 percent / Bu₄NBr, NaOH / diethyl ether; CH₂Cl₂ / Ambient temperature

With pyridine; dmap; sodium hydroxide; PPA; hydroxylamine hydrochloride; tetrabutylammomium bromide; sodium acetate; triethylamine; trifluoroacetic anhydride; zinc; In diethyl ether; ethanol; dichloromethane; chloroform; acetic acid;
DOI:10.1002/ardp.19963290803