Glycyrrhizic acid ammonium salt

Base Information

• Chemical Name: Glycyrrhizic acid ammonium salt
• CAS No.: 53956-04-0
• Molecular Formula: C42H62O16^.NH3
• Molecular Weight: 839.975
• Hs Code.: 29389090
• NSC Number: 35348,2800
• ChEMBL ID: CHEMBL4436500
• Mol file: 53956-04-0.mol

Synonyms:NSC2800;Glycyrrhizic acid ammonium salt;C42H62O16.H3N;NSC-2800;NSC-35348;C42-H62-O16.H3-N;.alpha.-D-Glucopyranosiduronic acid,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt;Glycyrrhizicacidammoniumsalt;CHEMBL4436500;BCP33968;NSC35348;AS-82386;PD056311;FT-0658713;Monoammonium glycyrrhizinate;5-[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]-6-[(11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy]-3,4-dihydroxyoxane-2-carboxylic acid amine

Chemical Property of Glycyrrhizic acid ammonium salt

Chemical Property:

• Appearance/Colour: white to slightly yellow powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: >200°C (dec.)
• Refractive Index: 49 ° (C=1.5, EtOH)
• Boiling Point: 996.6 °C at 760 mmHg
• Flash Point: 556.6 °C
• PSA: 272.70000
• Density: 1.43g/cm3
• LogP: 0.32860
• Storage Temp.: 2-8°C
• Solubility.: Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
• Hydrogen Bond Donor Count: 9
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 7
• Exact Mass: 839.43033499
• Heavy Atom Count: 59
• Complexity: 1730

Purity/Quality:

≥73% ^*data from raw suppliers

Monoammonium glycyrrhizinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N
• Description: § 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
• Uses: Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated. pharmaceutical excipient, GRAS, sweetener Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.

Technology Process of Glycyrrhizic acid ammonium salt

There total 1 articles about Glycyrrhizic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

→ Glycyrrhizin ammonium (53956-04-0,1407-03-0)

Guidance literature:

Reference yield: 97.0%

sulfadimesine (57-68-1) + Glycyrrhizin ammonium (53956-04-0,1407-03-0) → C42H62O16*C12H14N4O2S*H3N

Guidance literature:

at 20 ℃;

DOI:10.1023/A:1012382904059

Reference yield: 97.0%

Glycyrrhizin ammonium (53956-04-0,1407-03-0) + 2-[p-(phthalylamino)benzenesulfamido]thiazole → C42H62O16*C17H13N3O5S2*H3N

Guidance literature:

at 20 ℃;

DOI:10.1023/A:1012382904059

Downstream raw materials:

enoxolone

Refernces