N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide

Base Information

• Chemical Name: N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide
• CAS No.: 1221740-98-2
• Molecular Formula: C₁₇H₂₉NO₃SSi
• Molecular Weight: 355.574
• Mol file: 1221740-98-2.mol

Synonyms:N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide

Chemical Property of N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide

There total 6 articles about N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Chloroethanesulfonyl chloride (1622-32-8) + 3-(2-(tert-butyldimethylsilyloxy)phenyl)propan-1-amine (1221740-97-1) → N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide (1221740-98-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol1003669

Reference yield: 84.0%

2-Chloroethanesulfonyl chloride (1622-32-8) + C16H29NOSi → N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide (1221740-98-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201001402

Reference yield:

C16H27NO2Si (1261034-10-9) → N-(3-(2-(tert-butyldimethylsilyloxy)phenyl)propyl)ethene sulfonamide (1221740-98-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;

DOI:10.1002/chem.201001402

upstream raw materials:

2-Chloroethanesulfonyl chloride

3-(2-(tert-butyldimethylsilyloxy)phenyl)propan-1-amine

C₁₆H₂₇NO₂Si

3,4-dihydro-6-methyl-2H-1-benzopyran-2-one

Downstream raw materials:

N-(3-(2-hydroxyphenyl)propyl)ethenesulfonamide

Refernces

• 1、 Liang, Huan,Ciufolini, Marco A.. "Oxidative spirocyclization of phenolic sulfonamides: Scope and applications". . p. 13262 - 13270. Retrieved 2011/03/17.