N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide

Base Information

• Chemical Name: N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide
• CAS No.: 1161419-74-4
• Molecular Formula: C₂₆H₂₁FNO₂P
• Molecular Weight: 429.43
• Mol file: 1161419-74-4.mol

Synonyms:N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide

Chemical Property of N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide

There total 1 articles about N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

diphenylphosphinamide (5994-87-6) + 3-fluoro-4'-methoxybiphenyl-4-carbaldehyde (716344-22-8) → N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide (1161419-74-4)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.03.075

Reference yield: 30.0%

diiodomethane (75-11-6) + N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide (1161419-74-4) + hex-1-yne (693-02-7) → N-(R*)-{[(1R*,2R*)-2-butylcyclopropyl]-[4'-methoxy-2-fluoro-4-(phenyl)phenyl]methyl}-P,P-diphenylphosphinamide

Guidance literature:

hex-1-yne; With Schwartz's reagent; In dichloromethane; at 80 ℃; for 0.0166667h; Microwave irradiation; Inert atmosphere;

With dimethyl zinc(II); In dichloromethane; toluene; at -78 - 0 ℃; Inert atmosphere;

diiodomethane; N-[4-(4'-methyloxy)-2-fluorobiphenylmethylidene]-P,P-diphenylphosphinamide; Further stages;

DOI:10.1016/j.bmcl.2009.03.075

upstream raw materials:

diphenylphosphinamide

3-fluoro-4'-methoxybiphenyl-4-carbaldehyde