7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

Base Information

Chemical Name:7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester
CAS No.:33458-77-4
Molecular Formula:C₂₇H₂₁NO₆
Molecular Weight:455.467
Hs Code.:

7,14-dihydro-12b<i>H</i>-[1,3]dioxolo[4,5-<i>i</i>][1,3]dioxolo[4',5':4,5]benzo[1,2-<i>c</i>]phenanthridine-13-carboxylic acid benzyl ester

Synonyms:7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

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Chemical Property of 7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

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Technology Process of 7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

There total 11 articles about 7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1375467-87-0
C₃₆H₄₁NO₆Si

: 33458-77-4
7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

: 1375467-90-5
C₂₇H₂₁NO₆

Guidance literature:: C₃₆H₄₁NO₆Si; In acetonitrile; at 80 ℃; for 1h; Inert atmosphere;

In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile; at 120 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300967a

Reference yield:

: (5,6-dihydro-cyclobuta[4,5]benzo[1,2-d][1,3]dioxol-5-yl)-(5-ethynyl-benzo[1,3]dioxol-4-ylmethyl)-carbamic acid benzyl ester

: 33458-77-4
7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

Guidance literature:: In o-xylene;
DOI:10.1021/ja00744a085

Reference yield:

: 1375467-83-6
C₁₉H₂₆O₃Si

: 33458-77-4
7,14-dihydro-12bH-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine-13-carboxylic acid benzyl ester

: 1375467-89-2
C₂₇H₁₉NO₆

Guidance literature:: Multi-step reaction with 5 steps

1: triethylsilane; trifluoroacetic acid / acetonitrile / 18 h / 0 - 20 °C / Inert atmosphere

2: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / tetrahydrofuran / 87 h / 80 °C / Inert atmosphere

3: tetrabutylammonium triphenyldifluorosilicate / 1,4-dioxane / 96 h / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere

5: 5,5-dimethyl-1,3-cyclohexadiene / 1 h / 120 °C / Inert atmosphere

With triethylsilane; copper(l) iodide; tetrabutyl ammonium fluoride; caesium carbonate; tetrabutylammonium triphenyldifluorosilicate; trifluoroacetic acid; N,N`-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile; 5: Diels-Alder reaction;
DOI:10.1021/ol300967a