16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

Base Information

Chemical Name:16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate
CAS No.:1470067-89-0
Molecular Formula:C₃₁H₃₆N₂O₄
Molecular Weight:500.638
Hs Code.:

Synonyms:16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

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Technology Process of 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

There total 4 articles about 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.2%

: 288-13-1
NH-pyrazole

: 1470067-71-0
16-formyl-17-chloroandrost-5,16-diene-3β-yl p-methoxybenzoate

: 1470067-89-0
16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.02.031

Reference yield:

: 100-09-4
4-methoxybenzoic acid

: 1470067-89-0
16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; dmap / chloroform / 2 h / 20 °C

2: trichlorophosphate / chloroform / 5 h / Reflux; Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With dmap; caesium carbonate; dicyclohexyl-carbodiimide; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.02.031

Reference yield:

: 1332323-44-0
17-oxaandrost-5-ene-3β-yl p-methoxybenzoate

: 1470067-89-0
16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / chloroform / 5 h / Reflux; Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

With caesium carbonate; trichlorophosphate; In chloroform; N,N-dimethyl-formamide; 1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.02.031