4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

Base Information

Chemical Name:4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid
CAS No.:1073613-03-2
Molecular Formula:C₁₆H₁₀F₃N₃O₂S
Molecular Weight:365.336
Hs Code.:

Synonyms:4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

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Chemical Property of 4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

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Technology Process of 4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

There total 3 articles about 4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1073613-02-1
3-trifluoromethyl-[[(4-carboxyphenyl)amino]thioxomethyl]benzoic acid hydrazide

: 1073613-03-2
4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

Guidance literature:: With sulfuric acid; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2008.07.044

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1073613-03-2
4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; hydrazine hydrate / 0 °C

2: tetrahydrofuran / 2 h / Reflux

3: sulfuric acid / 0.5 h / 20 °C

With pyridine; sulfuric acid; hydrazine hydrate; In tetrahydrofuran;

Reference yield:

: 22227-25-4
3-(trifluoromethyl)benzene-1-carbohydrazide

: 1073613-03-2
4-[(5-(3-trifluoromethylphenyl)-1,3,4-thiadiazol-2-yl)amino]benoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / Reflux

2: sulfuric acid / 0.5 h / 20 °C

With sulfuric acid; In tetrahydrofuran;