ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

Base Information

Chemical Name:ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate
CAS No.:134477-43-3
Molecular Formula:C₂₂H₃₂N₂O₆
Molecular Weight:420.506
Hs Code.:

Synonyms:ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

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Chemical Property of ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

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Technology Process of ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

There total 6 articles about ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 134477-42-2
ethyl 5-<8-<(benzyloxycarbonyl)amino>oct-1-en-2-yl>oxazoline-4-carboxylate

: 134477-43-3
ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

Guidance literature:: With water; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm00075a029

Reference yield:

: 19008-71-0
8-aminooctan-1-ol

: 134477-43-3
ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / NaHCO₃ / acetone; H₂O / 21 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

3: piperazine, AcOH / H₂O / 1 h / Heating

4: 33 percent / Cu₂O / toluene / 3 h / 40 °C

5: 100 percent / H₂O / tetrahydrofuran / 4 h / Heating

With piperazine; copper(I) oxide; oxalyl dichloride; water; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1021/jm00075a029

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 134477-43-3
ethyl 10-<(benzyloxycarbonyl)amino>-2-(formylamino)-3-hydroxy-4-methylenedecanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / NaHCO₃ / acetone; H₂O / 21 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) N-ethyldiisopropylamine / 1.) CH₂Cl₂, -60 to -50 deg C, 30 min, 2.) CH₂Cl₂, -50 deg C, 1 h

3: piperazine, AcOH / H₂O / 1 h / Heating

4: 33 percent / Cu₂O / toluene / 3 h / 40 °C

5: 100 percent / H₂O / tetrahydrofuran / 4 h / Heating

With piperazine; copper(I) oxide; oxalyl dichloride; water; sodium hydrogencarbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1021/jm00075a029