6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

Base Information

Chemical Name:6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt
CAS No.:96661-40-4
Molecular Formula:C₂₆H₂₉N₄O₅S*K
Molecular Weight:548.704
Hs Code.:

6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

Synonyms:6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

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Chemical Property of 6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

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Technology Process of 6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

There total 4 articles about 6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 96661-36-8
p-bromophenacyl-6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

: 96661-40-4
6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

Guidance literature:: With potassium thiophenolate; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 591-51-5
phenyllithium

: 96661-40-4
6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / -78 °C

2: tetrahydrofuran / 12 h / 25 °C

3: 1.) trimethylacetyl chloride, triethylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, 0 deg C, 8 h

4: 54 percent / potassium thiophenoxide / dimethylformamide / 1 h / 0 °C

With potassium thiophenolate; pivaloyl chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 3-(4',4'-dimethyl-4',5'-dihydro-oxazol-2'-yl)-N-lithio-4-phenyl-1,4-dihydropyridine

: 96661-40-4
6-β-<<4-phenyl-3-(4,4-dimethyloxazolin-2-yl)-1,4-dihydropyridylacetyl>amino>-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylic acid potassium salt

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 12 h / 25 °C

2: 1.) trimethylacetyl chloride, triethylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, 0 deg C, 8 h

3: 54 percent / potassium thiophenoxide / dimethylformamide / 1 h / 0 °C

With potassium thiophenolate; pivaloyl chloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;