1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

Base Information

Chemical Name:1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine
CAS No.:552885-90-2
Molecular Formula:C₃₆H₄₆F₃N₅O
Molecular Weight:621.789
Hs Code.:

Synonyms:1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

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Chemical Property of 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

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Technology Process of 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

There total 2 articles about 1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₄ClF₃ON₄

: 552885-90-2
1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1248/cpb.55.1044

Reference yield:

: (+/-)-2,2-bis(4-fluorophenyl)-5-{4-[2-(4-fluorophenyl)-2-(4-isopropylpiperazin-1-yl)ethyl]piperazin-1-yl}pentanoic acid tetrakis-hydrochloride

: 552885-90-2
1-[2-(4-fluorophenyl)-2-(4-isopropylpiperazino)ethyl]-4-[4,4-bis-(4-fluorophenyl)-4-carbamoylbutyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / benzene / 2 h / 80 °C

2: 80 mg / aq. NH₃ / tetrahydrofuran / 1 h / 20 °C

With ammonium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; benzene;
DOI:10.1248/cpb.55.1044