N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide

Base Information

• Chemical Name: N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide
• CAS No.: 950738-59-7
• Molecular Formula: C₁₉H₁₇F₃N₂O₂
• Molecular Weight: 362.351
• Mol file: 950738-59-7.mol

Synonyms:N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide

Chemical Property of N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide

There total 1 articles about N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(3-Acetyl-phenyl)-3-trifluoromethyl-benzamide (440348-37-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide (950738-59-7)

Guidance literature:

at 100 ℃; for 18h;

DOI:10.1016/j.bmcl.2009.10.074

Reference yield: 91.0%

N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide (950738-59-7) + 3-aminopyrazole (1820-80-0,916420-28-5) → N-(3-pyrazolo[1,5-a]pyrimidin-7-ylphenyl)-3-(trifluoromethyl)benzamide (950195-00-3)

Guidance literature:

In acetic acid; at 110 ℃; for 4h;

Reference yield: 80.0%

N-[3-(3-dimethylaminoacryloyl)phenyl]-3-trifluoromethylbenzamide (950738-59-7) + C7H12N4O (756814-98-9) → N-(3-(2-morpholinopyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide

Guidance literature:

With acetic acid; at 80 ℃; for 18h;

DOI:10.1016/j.bmcl.2009.10.074

upstream raw materials:

N-(3-Acetyl-phenyl)-3-trifluoromethyl-benzamide

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

N-(3-pyrazolo[1,5-a]pyrimidin-7-ylphenyl)-3-(trifluoromethyl)benzamide

N-[3-(3-bromo-pyrazolo[1,5-a]pyrimidin-7-yl)-phenyl]-3-trifluoromethyl-benzamide