(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

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Chemical Name:(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene
CAS No.:217939-79-2
Molecular Formula:C₁₇H₂₂O₄
Molecular Weight:290.359
Hs Code.:

Synonyms:(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

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Chemical Property of (2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

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Technology Process of (2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

There total 3 articles about (2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 217939-77-0
(2R,4S,5R)-4-Allyl-5-((S)-1-ethyl-allyloxy)-2-(4-methoxy-phenyl)-[1,3]dioxane

: 217939-79-2
(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

Guidance literature:: Grubbs catalyst first generation; In benzene; for 12h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01825-5

Reference yield:

: (S)-2-[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-butyraldehyde

: 217939-79-2
(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / 12 h / Ambient temperature

2: 94 percent / PhCHRu(PCy₃)2Cl₂ / benzene / 12 h / Ambient temperature

With n-butyllithium; Grubbs catalyst first generation; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(98)01825-5

Reference yield:

: (S)-2-[(2R,4S,5R)-4-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yloxy]-butan-1-ol

: 217939-79-2
(2R,4aR,6S,9aS)-6-Ethyl-2-(4-methoxy-phenyl)-4a,6,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) (COCl)2, DMSO; 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 1 h; 2.) -60 deg C to r.t.

2: n-BuLi / tetrahydrofuran / 12 h / Ambient temperature

3: 94 percent / PhCHRu(PCy₃)2Cl₂ / benzene / 12 h / Ambient temperature

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; Grubbs catalyst first generation; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(98)01825-5