2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

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Chemical Name:2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid
CAS No.:1445830-66-9
Molecular Formula:C₂₅H₂₂Cl₂N₆O₃
Molecular Weight:525.394
Hs Code.:

Synonyms:2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

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Chemical Property of 2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

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Technology Process of 2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

There total 5 articles about 2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 120100-50-7
methyl-3-bromomethyl-2,4-dichlorobenzoate

: 1445831-54-8
2-(5-cyclopropyl-4-methyl-1H-pyrazol-3-yl)-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

: 1445830-66-9
2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; paraffin oil; at 20 ℃; for 20h;

Reference yield:

: 1445831-35-5
2-[5-cyclopropyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxypyrimidin-4-amine

: 1445830-66-9
2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 2 h / 105 °C / Inert atmosphere

2: trifluoroacetic acid; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 20 - 75 °C

3: sodium hydride / tetrahydrofuran; paraffin oil / 20 h / 20 °C

With trifluorormethanesulfonic acid; palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; paraffin oil;

Reference yield:

: 1445830-48-7
2-[5-cyclopropyl-1-(2-fluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

: 1445830-66-9
2,4-dichloro-3-({5-cyclopropyl-3-[5-methoxy-4-((pyridin-4-yl)amino)pyrimidin-2-yl]-4-methyl-1H-pyrazol-1-yl}methyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate; oxygen / dimethyl sulfoxide; tetrahydrofuran / 5 h / 20 °C

2: sodium hydride / tetrahydrofuran; paraffin oil / 20 h / 20 °C

With potassium tert-butylate; oxygen; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; paraffin oil;