5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

Base Information

• Chemical Name: 5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one
• CAS No.: 1352052-18-6
• Molecular Formula: C₆H₃BrFN₃OS
• Molecular Weight: 264.078
• Mol file: 1352052-18-6.mol

Synonyms:5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

Chemical Property of 5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

There total 1 articles about 5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl-2-fluoroacetoacetate (1522-41-4) + 5-bromo-2-amino-1,3,4-thiadiazole (37566-39-5) → 5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (1352052-18-6)

Guidance literature:

With polyphosphoric acid; at 100 ℃; for 8h;

DOI:10.1002/jhet.767

Reference yield: 92.0%

5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (1352052-18-6) + 3,4-dimethyl phenylboronic acid (55499-43-9) → 6-fluoro-7-methyl-2-(3,4-dimethylphenyl)-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h;

DOI:10.1039/c6ra22750c

Reference yield: 92.0%

5H-2-bromo-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (1352052-18-6) + phenylboronic acid (98-80-6) → 6-fluoro-7-methyl-2-phenyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (1352052-23-3)

Guidance literature:

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h;

DOI:10.1039/c6ra22750c

upstream raw materials:

ethyl-2-fluoroacetoacetate

5-bromo-2-amino-1,3,4-thiadiazole

Downstream raw materials:

5H-6-fluoro-2-(N'-benzylidene-hydrazino)-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

5H-2-(N'-phenylhydrazino)-6-fluoro-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one

6-fluoro-7-methyl-2-phenyl-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one