(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

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Chemical Name:(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester
CAS No.:761435-53-4
Molecular Formula:C₃₂H₃₉NO₈S
Molecular Weight:597.73
Hs Code.:

Synonyms:(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

There total 6 articles about (S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 761435-51-2
(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-pent-4-enoic acid tert-butyl ester

: 761435-53-4
(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

Guidance literature:: With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

: 146398-01-8
(R)-4-hydroxy-2-{[(phenylmethoxy)carbonyl]amino}butanoic acid 1,1-dimethylethyl ester

: 761435-53-4
(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / TEA / CH₂Cl₂

2: 60 percent / NaH / dimethylformamide / 20 °C

3: 95 percent / K₂CO₃ / dimethylformamide

4: 90 percent / LDA / tetrahydrofuran

5: 90 percent / Oxone / methanol; H₂O

6: 67 percent / 9-BBN / tetrahydrofuran

With Oxone; 9-borabicyclo[3.3.1]nonane dimer; TEA; sodium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049

Reference yield:

: 71449-08-6
(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

: 761435-53-4
(S)-2-[(R)-2-(4-Benzyloxy-benzenesulfonyl)-1-benzyloxycarbonylamino-ethyl]-5-hydroxy-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / BH₃ / tetrahydrofuran

2: 97 percent / TEA / CH₂Cl₂

3: 60 percent / NaH / dimethylformamide / 20 °C

4: 95 percent / K₂CO₃ / dimethylformamide

5: 90 percent / LDA / tetrahydrofuran

6: 90 percent / Oxone / methanol; H₂O

7: 67 percent / 9-BBN / tetrahydrofuran

With Oxone; 9-borabicyclo[3.3.1]nonane dimer; TEA; borane; sodium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.049