(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

Base Information

Chemical Name:(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate
CAS No.:288094-34-8
Molecular Formula:C₄₁H₄₂FNO₂
Molecular Weight:599.788
Hs Code.:

Synonyms:(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

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Chemical Property of (R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

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Technology Process of (R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

There total 3 articles about (R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 15110-93-7
2-fluoro-N-(phenylmethylene)benzeneamine

: 221149-44-6,221150-50-1
acetic acid 2,2''-diisopropyl-4',6'-dimethyl-[1,1';3',1'']terphenyl-2'-yl ester

: 288094-34-8
(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

Guidance literature:: acetic acid 2,2''-diisopropyl-4',6'-dimethyl-[1,1';3',1'']terphenyl-2'-yl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

2-fluoro-N-(phenylmethylene)benzeneamine; With diethylzinc; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1016/S0040-4020(00)01042-5

Reference yield: 55.0%

: 164362-53-2
(E)-2-fluoro-N-(phenylmethylene)benzenamine

: 221149-44-6,221150-50-1
acetic acid 2,2''-diisopropyl-4',6'-dimethyl-[1,1';3',1'']terphenyl-2'-yl ester

: 288094-34-8
(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

Guidance literature:: acetic acid 2,2''-diisopropyl-4',6'-dimethyl-[1,1';3',1'']terphenyl-2'-yl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(E)-2-fluoro-N-(phenylmethylene)benzenamine; With diethylzinc; In tetrahydrofuran; hexane; at -78 ℃; Further stages.;
DOI:10.1021/ol000099e

Reference yield:

: 194414-17-0,194497-09-1,194497-11-5,194497-13-7
2,6-bis(2-isopropylphenyl)-3,5-dimethylphenol

: 288094-34-8
(R,R)-2,6-bis(2-isopropylphenyl)-3,5-dimethylphenyl 3-(2-fluorophenyl)amino-3-phenylpropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: 1.78 g / tetrahydrofuran; hexane / 1.5 h / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 83 percent / Et₂Zn / tetrahydrofuran; hexane / -78 °C

With n-butyllithium; In tetrahydrofuran; hexane; 2.2: Mannich reaction;
DOI:10.1016/S0040-4020(00)01042-5