N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

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Chemical Name:N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine
CAS No.:911694-20-7
Molecular Formula:C₃₁H₃₆N₂O₂
Molecular Weight:468.639
Hs Code.:

Synonyms:N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

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Chemical Property of N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

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Technology Process of N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

There total 3 articles about N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 911694-13-8
N-[(1E)-[(2S)-5-iodo-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]-N-[(1S)-1-(methoxymethyl)-2-methylpropyl]amine

: 7294-51-1
2,4,6-tris(4-methoxyphenyl)boroxine

: 911694-20-7
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium tert-butylate; In tert-Amyl alcohol; for 12h; Heating;
DOI:10.1021/ol061415d

Reference yield: 83.0%

: 857900-11-9
N-{(1S)-1-[(methoxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

: 696-62-8
para-iodoanisole

: 911694-20-7
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

Guidance literature:: N-{(1S)-1-[(methoxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; silver orthophosphate; sodium acetate; In N,N-dimethyl-formamide; Inert atmosphere;

para-iodoanisole; In N,N-dimethyl-formamide; at 150 ℃; for 6h; regioselective reaction;
DOI:10.1021/ol8018709

Reference yield:

: 857900-11-9
N-{(1S)-1-[(methoxy)methyl]-2-methylpropyl}-N-{(1E)-phenyl[(2S)-2-phenyl-3,4-dihydropyridin-1(2H)-yl]methylene}amine

: 911694-20-7
N-[(1S)-1-(methoxymethyl)-2-methylpropyl]-N-[(1E)-[(2S)-5-(4-methoxyphenyl)-2-phenyl-3,4-dihydropyridin-1(2H)-yl](phenyl)methylidene]amine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / I₂; Cs₂CO₃ / dioxane / 12 h / 65 °C

2: 85 percent / Pd(t-Bu₃P)2; t-BuOK / 2-methyl-butan-2-ol / 12 h / Heating

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium tert-butylate; iodine; caesium carbonate; In 1,4-dioxane; tert-Amyl alcohol; 2: Suzuki cross-coupling;
DOI:10.1021/ol061415d