Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

Base Information

Chemical Name:Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate
CAS No.:313478-67-0
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

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Chemical Property of Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

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Technology Process of Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

There total 8 articles about Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 313478-65-8
Methyl (S)-2,2-dimethyl-3-[N-(2'-methoxy-6'-methylphenyl)-N-((S)-tert-leucyl)]amino-3-phenylpropionate

: 313478-67-0
Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

Guidance literature:: Methyl (S)-2,2-dimethyl-3-[N-(2'-methoxy-6'-methylphenyl)-N-((S)-tert-leucyl)]amino-3-phenylpropionate; With pyridine; sodium hydroxide; phenyl isothiocyanate; at 20 ℃; for 3h;

With trifluoroacetic acid; In dichloromethane; Further stages.; Heating;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B

Reference yield:

: 220892-42-2
(E)-2-methoxy-6-methyl-N-(phenylmethylene)benzeneamine

: 313478-67-0
Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1.1: CH₂Cl₂ / 0.67 h / 0 - 20 °C

2.1: CH₂Cl₂ / 72 h / 20 °C

3.1: NaBH₄ / propan-2-ol; H₂O / 20 °C

3.2: 65 percent / aq. HCl / propan-2-ol / 80 °C / pH 1

4.1: phenylisothiocyanate; pyridine; aq. NaOH / 3 h / 20 °C

4.2: 45 percent / TFA / CH₂Cl₂ / Heating

With pyridine; sodium hydroxide; sodium tetrahydroborate; phenyl isothiocyanate; In dichloromethane; water; isopropyl alcohol; 1.1: Acylation / 2.1: Addition / 3.1: Reduction / 3.2: Hydrolysis / 4.1: Addition / 4.2: Acidolysis;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B

Reference yield:

: [(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3-dimethyl-butyryl]-(2-methoxy-6-methyl-phenyl)-[1-phenyl-meth-(E)-ylidene]-ammonium; chloride

: 313478-67-0
Methyl 2,2-dimethyl-(S)-3-(2'-methoxy-6'-methylphenyl)amino-3-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 72 h / 20 °C

2.1: NaBH₄ / propan-2-ol; H₂O / 20 °C

2.2: 65 percent / aq. HCl / propan-2-ol / 80 °C / pH 1

3.1: phenylisothiocyanate; pyridine; aq. NaOH / 3 h / 20 °C

3.2: 45 percent / TFA / CH₂Cl₂ / Heating

With pyridine; sodium hydroxide; sodium tetrahydroborate; phenyl isothiocyanate; In dichloromethane; water; isopropyl alcohol; 1.1: Addition / 2.1: Reduction / 2.2: Hydrolysis / 3.1: Addition / 3.2: Acidolysis;
DOI:10.1002/1521-3765(20000602)6:11<2032::AID-CHEM2032>3.0.CO;2-B