N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Base Information

Chemical Name:N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride
CAS No.:1256725-85-5
Molecular Formula:C₁₈H₁₉F₂NO₅S₂*ClH
Molecular Weight:467.942
Hs Code.:

Synonyms:N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

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Chemical Property of N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Chemical Property:

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Technology Process of N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

There total 8 articles about N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₇F₂NO₇S₂

: 1256725-85-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2017.07.071

Reference yield:

: C₁₇H₁₄BrF₂NO₄S

: 1256725-85-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 2 h / 0 °C / Heating

2: ethyl acetate / 2 h / 50 °C

3: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 °C

4: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 20 °C

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; borane-THF; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate;
DOI:10.1016/j.ejmech.2017.07.071

Reference yield:

: C₂₃H₂₇F₂NO₅S₂

: 1256725-85-5
N-[2-(2,5-difluorophenoxy)ethyl]-6-(methylsulfonyl)-3,4-dihydro-2H-thiochromen-4-amine 1,1-dioxide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 3 h / 20 °C

2: hydrogenchloride / ethyl acetate / 1 h / 20 °C

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In ethyl acetate;
DOI:10.1016/j.ejmech.2017.07.071