(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

Base Information

Chemical Name:(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate
CAS No.:1445591-81-0
Molecular Formula:C₁₆H₁₇BrN₂O₂
Molecular Weight:349.227
Hs Code.:

Synonyms:(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

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Chemical Property of (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

Chemical Property:

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Technology Process of (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

There total 6 articles about (1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1445591-80-9
(1S,2S)-1-(2-(4-bromophenyl)-2-oxoethyl) 2-methyl cyclopentane-1,2-dicarboxylate

: 1445591-81-0
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

Guidance literature:: With ammonium acetate; In toluene; at 100 ℃; for 10h; Sealed tube;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1445591-81-0
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / chloroform / 0 - 20 °C

1.2: 6 h / 0 °C

1.3: pH 5

2.1: acetic anhydride / 20 h / Reflux

3.1: quinine / toluene; tetrachloromethane / 60 h / -65 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

6.1: ammonium acetate / toluene / 10 h / 100 °C / Sealed tube

With ammonium acetate; bromine; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; chloroform; toluene; acetonitrile;

Reference yield:

: 1461-96-7
cis-1,2-cyclopentanedicarboxylic acid

: 1445591-81-0
(1S,2S)-methyl 2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride / 20 h / Reflux

2: quinine / toluene; tetrachloromethane / 60 h / -65 °C

3: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

5: ammonium acetate / toluene / 10 h / 100 °C / Sealed tube

With ammonium acetate; acetic anhydride; quinine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; tetrachloromethane; toluene; acetonitrile;