2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

Base Information

Chemical Name:2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole
CAS No.:1179925-39-3
Molecular Formula:C₂₈H₃₉F₂N₃O₂S₂Si
Molecular Weight:579.851
Hs Code.:

Synonyms:2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

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Chemical Property of 2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

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Technology Process of 2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

There total 1 articles about 2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 957109-18-1
methyl 2,2-difluoro-4-(triisopropylsilyl)-3-butynoate

: 1179925-25-7
2-(4-iodophenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

: 1179925-39-3
2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

Guidance literature:: methyl 2,2-difluoro-4-(triisopropylsilyl)-3-butynoate; 2-(4-iodophenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -110 - -78 ℃; Inert atmosphere;

With pyridine; hydroxylamine hydrochloride; In ethanol; at 60 ℃; for 4h; Further stages;
DOI:10.1016/j.bmc.2009.06.048

Reference yield: 97.0%

: 1179925-39-3
2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diaziridin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

: 1179925-41-7
2-(4-(3-(1,1-difluoro-3-triisopropylsilylprop-2-ynyl)diazirin-3-yl)phenylthio)-5-(4-methoxytetrahydropyran-4-yl)thiazole

Guidance literature:: With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.06.048