diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

Base Information

Chemical Name:diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate
CAS No.:73584-08-4
Molecular Formula:C₁₁H₁₆BrO₄P
Molecular Weight:323.123
Hs Code.:

Synonyms:diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

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Chemical Property of diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

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Technology Process of diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

There total 1 articles about diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3132-99-8
m-bromobenzoic aldehyde

: 762-04-9
phosphonic acid diethyl ester

: 73584-08-4
diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

Guidance literature:: With cholin hydroxide; In neat (no solvent); at 20 ℃; for 0.1h; Green chemistry;
DOI:10.1039/c6nj03948k

Reference yield: 94.0%

: 73584-08-4
diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

: 763141-59-9
diethyl [(3-bromophenyl)(fluoro)methyl]phosphonate

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; Petroleum ether; at -78 - 20 ℃; Inert atmosphere;

Reference yield:

: 73584-08-4
diethyl ((3-bromophenyl)(hydroxy)methyl)phosphonate

: 1401462-17-6
(Z)-methyl 4-(2-fluoro-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)vinyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane; Petroleum ether / -78 - 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 80 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; potassium acetate; lithium diisopropyl amide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; Petroleum ether;