4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
CAS No.:194031-46-4
Molecular Formula:C₃₅H₃₆N₂O₁₀
Molecular Weight:644.678
Hs Code.:

4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Synonyms:4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of 4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

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Technology Process of 4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

There total 4 articles about 4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 40608-06-8
levulinic anhydride

: 194031-44-2
1-[2'-O-(4,4'-Dimethoxytrityl)-β-D-arabinofuranosyl]uracil

: 194031-46-4
4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With Novozym 435; In 1,4-dioxane; Ambient temperature;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 194031-46-4
4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine, AgNO₃ / tetrahydrofuran

2: 97 percent / KF*2H₂O, 18-crown-6 / tetrahydrofuran / 48 h / Ambient temperature

3: 93 percent / Novozym 435 / dioxane / Ambient temperature

With pyridine; potassium fluoride; Novozym 435; 18-crown-6 ether; silver nitrate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 104477-70-5
5',3'-O-(tetraisopropyldisiloxane-1,3-di-yl)-1-β-D-arabinofuranosyl-uracil

: 194031-46-4
4-Oxo-pentanoic acid (2R,3R,4S,5R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine, AgNO₃ / tetrahydrofuran

2: 97 percent / KF*2H₂O, 18-crown-6 / tetrahydrofuran / 48 h / Ambient temperature

3: 93 percent / Novozym 435 / dioxane / Ambient temperature

With pyridine; potassium fluoride; Novozym 435; 18-crown-6 ether; silver nitrate; In tetrahydrofuran; 1,4-dioxane;