1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Chemical Name:1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone
CAS No.:1313705-23-5
Molecular Formula:C₂₅H₂₃F₅N₆O₂S
Molecular Weight:566.555
Hs Code.:

1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Synonyms:1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Chemical Property of 1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Technology Process of 1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

There total 4 articles about 1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922516-43-6
2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl chloride

: 1313705-41-7
5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolo[3,4-c]pyrrole

: 1313705-23-5
1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: With trifluoroacetic acid; In chloroform; at 0 - 20 ℃; for 2h;

Reference yield:

: 141449-85-6
tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate

: 1313705-23-5
1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: pyridine / chloroform / 5 h / 90 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3.2: pH 12

4.1: trifluoroacetic acid / chloroform / 2 h / 0 - 20 °C

With pyridine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;

Reference yield:

: 1253189-14-8
2-chloro-1-[5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl]ethanone

: 1313705-23-5
1-[5-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-3-isoxazolyl]-2-thiazolyl]hexahydropyrrolol[3,4-c]pyrrol-2(1H)-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / chloroform / 5 h / 90 °C

2.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

2.2: pH 12

3.1: trifluoroacetic acid / chloroform / 2 h / 0 - 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane; chloroform;