methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate
CAS No.:1395997-00-8
Molecular Formula:C₂₀H₁₇F₃N₂O₄
Molecular Weight:406.361
Hs Code.:

Synonyms:methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Suppliers and Price of methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

There total 2 articles about methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1355011-30-1
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

: 1374656-55-9
4-(bromomethyl)tetrahydro-2H-pyran-4-carbonitrile

: 1395997-00-8
methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 168h;

Reference yield:

: 1010836-56-2
4-(hydroxymethyl)-tetrahydro-2H-pyran-4-carbonitrile

: 1395997-00-8
methyl 6-(4-((4-cyanotetrahydro-2H-pyran-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; bromine / dichloromethane / 120 h / 20 - 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 168 h / 70 °C

With bromine; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;