methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate

Base Information

• Chemical Name: methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate
• CAS No.: 1012057-50-9
• Molecular Formula: C₂₄H₂₆ClFN₄O₄
• Molecular Weight: 488.946

Synonyms:methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate

Chemical Property of methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate

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Technology Process of methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate

There total 2 articles about methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N4-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine (179552-75-1) + methyl 8-chloro-8-oxooctanoate (41624-92-4) → methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate (1012057-50-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.33333h;

DOI:10.1021/jm901453q

Reference yield: 78.0%

→ methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate (1012057-50-9)

Guidance literature:

Reference yield: 30.0%

methyl 8-(4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ylamino)-8-oxooctanoate (1012057-50-9) → N(1)-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-N(8)-hydroxyoctanediamide

Guidance literature:

With hydroxylamine; In methanol; at 0 - 25 ℃;

DOI:10.1021/jm901453q

upstream raw materials:

N⁴-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4,6-diamine

methyl 8-chloro-8-oxooctanoate

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