((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane
CAS No.:1536054-12-2
Molecular Formula:C₃₈H₅₈O₇Si
Molecular Weight:654.96
Hs Code.:

((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

Synonyms:((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

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Chemical Property of ((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

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Technology Process of ((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

There total 9 articles about ((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 1536054-10-0
(2S,5S)-1-((4S,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-ol

: 1536054-12-2
((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol403566w

Reference yield:

: 1536053-93-6
C₂₃H₃₀Br₂O₃Si

: 1536054-12-2
((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 3 h / 80 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether / 2 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - -40 °C / Inert atmosphere

2.3: 2 h / -78 - -10 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; tert.-butyl lithium; sodium methylate; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol403566w

Reference yield:

: 1536053-95-8
(2S,4S)-4-((R)-3-bromobut-3-en-2-yl)-2-(4-methoxyphenyl)-1,3-dioxane

: 1536054-12-2
((2S,5S)-1-((4R,6S)-6-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)-5-((2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)-4-methylenehexan-2-yloxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / diethyl ether / 2 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - -40 °C / Inert atmosphere

1.3: 2 h / -78 - -10 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; tert.-butyl lithium; In diethyl ether; dichloromethane;
DOI:10.1021/ol403566w