6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide

Base Information

• Chemical Name: 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide
• CAS No.: 170728-33-3
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 170728-33-3.mol

Synonyms:6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide

Chemical Property of 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide

There total 7 articles about 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-benzyloxy-2,2,5,7-tetramethylchroman-8-carbonitrile (170728-32-2) → 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide (170728-33-3)

Guidance literature:

With potassium hydroxide; 18-crown-6 ether; In diethylene glycol; at 135 ℃; for 48h;

DOI:10.1002/ardp.19963290106

Reference yield:

2,2,5,7-tetramethyl-6-chromanol (14074-92-1) → 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide (170728-33-3)

Guidance literature:

Multi-step reaction with 5 steps

2: 98 percent / NaH / dimethylformamide / 0.67 h / 0 °C

3: 98 percent / NH₂OH*HCl / H₂O; methanol / 3.33 h / 90 °C

4: 97 percent / Ac₂O / 3.33 h / Heating

5: 83 percent / 40percent aq. KOH, 18-crown-6 / bis-(2-hydroxy-ethyl) ether / 48 h / 135 °C

With potassium hydroxide; 18-crown-6 ether; hydroxylamine hydrochloride; acetic anhydride; sodium hydride; In methanol; water; N,N-dimethyl-formamide; diethylene glycol;

DOI:10.1002/ardp.19963290106

Reference yield:

1,4-dihydroxy-2,6-dimethylbenzene (654-42-2) → 6-benzyloxy-2,2,5,7-tetramethylchroman-8-carboxamide (170728-33-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 79 percent / ZnCl₂, silica gel, conc. HCl / CCl₄ / 1.33 h / Heating

3: 98 percent / NaH / dimethylformamide / 0.67 h / 0 °C

4: 98 percent / NH₂OH*HCl / H₂O; methanol / 3.33 h / 90 °C

5: 97 percent / Ac₂O / 3.33 h / Heating

6: 83 percent / 40percent aq. KOH, 18-crown-6 / bis-(2-hydroxy-ethyl) ether / 48 h / 135 °C

With hydrogenchloride; potassium hydroxide; 18-crown-6 ether; hydroxylamine hydrochloride; acetic anhydride; silica gel; sodium hydride; zinc(II) chloride; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide; diethylene glycol;

DOI:10.1002/ardp.19963290106

upstream raw materials:

6-benzyloxy-2,2,5,7-tetramethylchroman-8-carbonitrile

2,2,5,7-tetramethyl-6-chromanol

1,4-dihydroxy-2,6-dimethylbenzene

2,6-dimethyl-1,4-benzoquinone