N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

Base Information

Chemical Name:N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide
CAS No.:1382723-07-0
Molecular Formula:C₂₄H₂₂F₃NO₂
Molecular Weight:413.439
Hs Code.:

Synonyms:N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

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Chemical Property of N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

Chemical Property:

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Technology Process of N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

There total 5 articles about N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52085-14-0
4-benzoxy-salicylaldehyde

: 1382723-07-0
N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Sealed tube; Reflux

3: ammonium acetate / 50 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling / 3: Henry reaction;
DOI:10.1021/jm300544c

Reference yield:

: C₂₂H₂₀F₃NO

: 108-24-7
acetic anhydride

: 1382723-07-0
N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm300544c

Reference yield:

: 1382722-75-9
5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-carbaldehyde

: 1382723-07-0
N-(2-(5-(benzyloxy)-3'-(trifluoromethyl)[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate / 50 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium acetate; triethylamine; In tetrahydrofuran; dichloromethane; 1: Henry reaction;
DOI:10.1021/jm300544c