2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Base Information

Chemical Name:2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine
CAS No.:1445381-21-4
Molecular Formula:C₂₄H₂₅F₂N₃O₄
Molecular Weight:457.477
Hs Code.:

Synonyms:2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Suppliers and Price of 2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

There total 24 articles about 2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445381-19-0
1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1445381-21-4
2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Guidance literature:: 1-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3-fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; With dmap; Triphenylsilyl chloride; triethylamine; In acetonitrile; at 20 ℃;

With ammonium hydroxide; In acetonitrile; for 2h;

Reference yield:

: C₃₉H₄₆F₂N₂O₇S

: 1445381-21-4
2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Guidance literature:: With ammonium hydroxide; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jm5017279

Reference yield:

: C₅₃H₆₃FN₂O₈Si₂

: 1445381-21-4
2'-deoxy-3',5'-O-dibenzyl-2'-fluoro-4'-fluoromethylcytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

1.2: 5 h / 20 °C

2.1: diethylamino-sulfur trifluoride / toluene / -78 - 60 °C

3.1: water / acetonitrile / 20 °C

4.1: Triphenylsilyl chloride; dmap; triethylamine / acetonitrile / 20 °C

4.2: 2 h

With dmap; Triphenylsilyl chloride; diethylamino-sulfur trifluoride; water; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; acetonitrile;