5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

Base Information

Chemical Name:5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile
CAS No.:713496-87-8
Molecular Formula:C₂₃H₂₀N₂O₅
Molecular Weight:404.422
Hs Code.:

Synonyms:5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

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Technology Process of 5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

There total 5 articles about 5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 713496-95-8
1-iodo-2-(3-methoxy-prop-1-ynyl)-benzene

: 713496-94-7
2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

: 713496-87-8
5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 20 ℃;
DOI:10.1016/j.bmcl.2004.02.096

Reference yield:

: 615-42-9
1,2-Diiodobenzene

: 713496-87-8
5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 20 °C

2: 98 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; 1: Sonogashira coupling / 2: Sonogashira coupling;
DOI:10.1016/j.bmcl.2004.02.096

Reference yield:

: 149622-93-5
<(2-Nitrobenzyl)oxy>methyl chloride

: 713496-87-8
5-[2-(3-methoxy-prop-1-ynyl)-phenyl]-2-(2-nitro-benzyloxymethoxy)-pent-4-ynenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / NaH / tetrahydrofuran / 20 °C

2: aq. NH₃ / ethanol / 20 °C

3: Et₃N(+)SO₂N(-)CO₂Me / tetrahydrofuran / 20 °C

4: 98 percent / Pd(PPh₃)4; CuI; Et₃N / toluene / 20 °C

With ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Burgess Reagent; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; toluene; 4: Sonogashira coupling;
DOI:10.1016/j.bmcl.2004.02.096