2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

Base Information

Chemical Name:2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester
CAS No.:120569-09-7
Molecular Formula:C₁₉H₁₆N₂O₃
Molecular Weight:320.348
Hs Code.:

Synonyms:2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

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Chemical Property of 2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

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Technology Process of 2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

There total 9 articles about 2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 151-50-8
potassium cyanide

: 120569-08-6
2-[4-(2-Chloromethyl-4-cyano-phenoxy)-phenyl]-propionic acid methyl ester

: 120569-09-7
2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

Guidance literature:: In 1,4-dioxane; ethanol; water; for 2h; Heating;
DOI:10.1248/cpb.36.3462

Reference yield:

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 120569-09-7
2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / H₂ gas / platinic oxide / ethanol / Ambient temperature

2: 1.) NaNO₂, 2N HCl; 2.) cuprous cyanide / 1.) water, 0 deg C, 35 min; 2.) water, 60 deg C, 40 min

3: 33 percent / K₂CO₃, KI, copper powder / pyridine / 15 h / Heating

4: SOCl₂ / CHCl₃; dimethylformamide / 0.5 h / Heating

5: NaBH₄ / dioxane

6: 71 percent / SOCl₂ / CHCl₃ / 0.5 h / Heating

7: 73 percent / dioxane; ethanol; H₂O / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen; copper(l) cyanide; copper; potassium carbonate; potassium iodide; sodium nitrite; platinum(IV) oxide; In 1,4-dioxane; pyridine; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3462

Reference yield:

: 89-54-3
2-chloro-5-aminobenzoic acid

: 120569-09-7
2-[4-(4-Cyano-2-cyanomethyl-phenoxy)-phenyl]-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaNO₂, 2N HCl; 2.) cuprous cyanide / 1.) water, 0 deg C, 35 min; 2.) water, 60 deg C, 40 min

2: 33 percent / K₂CO₃, KI, copper powder / pyridine / 15 h / Heating

3: SOCl₂ / CHCl₃; dimethylformamide / 0.5 h / Heating

4: NaBH₄ / dioxane

5: 71 percent / SOCl₂ / CHCl₃ / 0.5 h / Heating

6: 73 percent / dioxane; ethanol; H₂O / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; copper(l) cyanide; copper; potassium carbonate; potassium iodide; sodium nitrite; In 1,4-dioxane; pyridine; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3462