N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

Base Information

Chemical Name:N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide
CAS No.:1452572-90-5
Molecular Formula:C₂₄H₂₈N₄O₃
Molecular Weight:420.511
Hs Code.:

Synonyms:N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

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Chemical Property of N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

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Technology Process of N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

There total 7 articles about N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452573-75-9
tert-butyl N-methyl-N-[1-[[5-[methyl(oxane-4-carbonyl)amino]-6-(2-phenyl-ethynyl)pyridin-2-yl]amino]-1-oxopropan-2-yl]carbamate

: 1452572-90-5
N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.66667h;

Reference yield:

: 1452573-52-2
tert-butyl N-methyl-N-[1-[[5-(oxane-4-carbonylamino)-6-(2-phenylethynyl)-pyridin-2-yl]amino]-1-oxopropan-2-yl]carbamate

: 1452572-90-5
N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

1.2: 0.33 h

2.1: trifluoroacetic acid / dichloromethane / 1.67 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 536-74-3
phenylacetylene

: 1452572-90-5
N-methyl-N-[6-[2-(methylamino)propanoylamino]-2-(2-phenyl-ethynyl)pyridin-3-yl]oxane-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine / acetonitrile; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 17 h

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: dicyclohexyl-carbodiimide / dichloromethane / 0.33 h / 20 °C

4.2: 144 h / 40 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

5.2: 0.33 h

6.1: trifluoroacetic acid / dichloromethane / 1.67 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;