Nimorazole

Base Information

• Chemical Name: Nimorazole
• CAS No.: 6506-37-2
• Molecular Formula: C9H14 N4 O3
• Molecular Weight: 226.235
• Hs Code.: 2934999090
• European Community (EC) Number: 229-394-4
• NSC Number: 107524
• UNII: 469ULX0H4G
• DSSTox Substance ID: DTXSID1057795
• Nikkaji Number: J8.420D
• Wikipedia: Nimorazole
• Wikidata: Q7037737
• NCI Thesaurus Code: C76425
• Metabolomics Workbench ID: 153208
• ChEMBL ID: CHEMBL435966
• Mol file: 6506-37-2.mol

Synonyms:Esclama;K 1900;K-1900;K1900;Naxogin;Nimorazole;Nitrimidazine;Nulogyl

Chemical Property of Nimorazole

Chemical Property:

• Vapor Pressure: 4.8E-08mmHg at 25°C
• Melting Point: 110-111°
• Refractive Index: 1.6300 (estimate)
• Boiling Point: 443°C at 760 mmHg
• PKA: 6.65±0.10(Predicted)
• Flash Point: 221.7°C
• PSA: 76.11000
• Density: 1.42g/cm³
• LogP: 0.58460
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 226.10659032
• Heavy Atom Count: 16
• Complexity: 239

Purity/Quality:

99% ^*data from raw suppliers

Nimorazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCN2C=NC=C2[N+](=O)[O-]
• Recent ClinicalTrials: AF CRT +/- Nimorazole in HNSCC
• Recent EU Clinical Trials: A randomized non-inferiority trial of hypoxia-profile guided hypoxic modification with nimorazole during radiotherapy/chemoradiotherapy of squamous cell carcinoma of the head and neck
• Description: Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities. It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM). Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg). Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.
• Uses: Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa.
• Therapeutic Function: Trichomonacidal

Technology Process of Nimorazole

There total 1 articles about Nimorazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ nimorazole (6506-37-2)

Guidance literature:

aus dem Bromoaethylimidazol III und Morpholin;

Refernces

• 1、 -. "Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction". . . Retrieved 2008/06/13.