2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

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Chemical Name:2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide
CAS No.:1312162-29-0
Molecular Formula:C₂₅H₂₉N₇O₃
Molecular Weight:475.55
Hs Code.:

Synonyms:2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

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Chemical Property of 2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

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Technology Process of 2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

There total 12 articles about 2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1312163-38-4
2-(2-(2-methoxy-4-morpholinophenylamino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

: 1312162-29-0
2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

Guidance literature:: 2-(2-(2-methoxy-4-morpholinophenylamino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide; With sulfuric acid; trifluoroacetic acid; at 20 ℃;

With sodium hydrogencarbonate; In water;

Reference yield:

: 209960-91-8
2-methoxy-4-morpholinoaniline

: 1312162-29-0
2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 - 150 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 - 150 °C

3: sulfuric acid; trifluoroacetic acid / 20 °C

With sulfuric acid; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;

Reference yield:

: 118-48-9
isatoic anhydride

: 1312162-29-0
2-(2-(2-methoxy-4-morpholinophenylamino)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; methanol / 16 h / 20 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 - 150 °C

3: sulfuric acid; trifluoroacetic acid / 20 °C

With sulfuric acid; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; toluene;