(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

Base Information

Chemical Name:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid
CAS No.:1073544-14-5
Molecular Formula:C₃₁H₃₇FO₄
Molecular Weight:492.631
Hs Code.:

Synonyms:(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

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Chemical Property of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

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Technology Process of (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

There total 7 articles about (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1073546-41-4
methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoate

: 1073544-14-5
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

Guidance literature:: methyl (3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoate; With sodium hydroxide; ethanol; water; In tetrahydrofuran; at 23 ℃; for 19h;

With hydrogenchloride; water; pH=1;

Reference yield:

: 1073547-36-0
(S)-methyl 3-(4-hydroxyphenyl)hept-4-ynoate

: 1073544-14-5
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium over charcoal / ethyl acetate / 5 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 17 h / 23 °C

3.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 19 h / 23 °C

3.2: pH 1

With sodium hydroxide; ethanol; water; hydrogen; caesium carbonate; palladium over charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 14034-08-3
methyl 3-bromo-4-(tert-butyl)benzoate

: 1073544-14-5
(3S)-3-(4-(((6-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-3-yl)methyl)oxy)phenyl)heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; toluene / 21 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3.1: thionyl chloride / dichloromethane / 16 h / 23 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 17 h / 23 °C

5.1: sodium hydroxide; ethanol; water / tetrahydrofuran / 19 h / 23 °C

5.2: pH 1

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ethanol; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;