(R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester

Base Information

• Chemical Name: (R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester
• CAS No.: 124312-30-7
• Molecular Formula: C₁₂H₁₆O₅
• Molecular Weight: 240.256
• Mol file: 124312-30-7.mol

Synonyms:(R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester

Chemical Property of (R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester

There total 1 articles about (R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(R)-Mandelic Acid (611-71-2) + chloromethyl methyl ether (107-30-2) → (R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester (124312-30-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h; Heating;

DOI:10.1016/0040-4020(89)80082-1

Reference yield: 100.0%

(R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester (124312-30-7) → (2R)-2-methoxymethoxy-3-phenylacetaldehyde (107536-09-4,120113-93-1,121842-15-7,121842-14-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;

DOI:10.1016/0040-4020(89)80082-1

Reference yield:

(R)-(-)-mandelic acid methoxymethyl ether methoxymethyl ester (124312-30-7) → (R)-2-phenylpropanal (93-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / diisobutylaluminium hydride / toluene / 2 h / -78 °C

2: 1.) t-BuLi / 1.) Et₂O, -78 deg C, 1 h; 2.) 1 h, -78 deg C

3: 70 percent / DMSO, oxalyl chloride / CH₂Cl₂ / 0.75 h / -78 °C

With oxalyl dichloride; tert.-butyl lithium; diisobutylaluminium hydride; dimethyl sulfoxide; In dichloromethane; toluene;

DOI:10.1016/0040-4020(89)80082-1

upstream raw materials:

(R)-Mandelic Acid

chloromethyl methyl ether

Downstream raw materials:

(2R)-2-methoxymethoxy-3-phenylacetaldehyde

(R)-2-phenylpropanal

(Z)-(R)-1-Methoxymethoxy-1,4-diphenyl-but-3-en-2-ol

(E)-(R)-1-Methoxymethoxy-1,4-diphenyl-but-3-en-2-ol