8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Base Information

• Chemical Name: 8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile
• CAS No.: 924848-43-1
• Molecular Formula: C₂₃H₁₉Cl₂N₃O
• Molecular Weight: 424.329
• Mol file: 924848-43-1.mol

Synonyms:8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Chemical Property of 8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile

There total 1 articles about 8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,5-bis(4-chlorobenzylidene)-1-methylpiperidin-4-one (104169-80-4) + malononitrile (109-77-3) → 8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile (924848-43-1)

Guidance literature:

With ammonium acetate; In N,N-dimethyl-formamide; at 120 ℃; for 0.116667h; chemoselective reaction; Microwave irradiation;

DOI:10.1055/s-0028-1088052

Reference yield: 61.0%

8-(4-chlorobenzylidene)-2-amino-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-6-methyl-4H-pyrano[3,2-c]pyridine-3-carbonitrile (924848-43-1) + 4-chlorobenzohydroximoyl chloride (28123-63-9) → 4-(4-chlorophenyl)-8-[(E)-(4-chlorophenyl)-methylidene]-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-6-methyl-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridin-2-ylamine (1313510-77-8)

Guidance literature:

With triethylamine; In benzene; for 5h; chemoselective reaction; Reflux;

DOI:10.1016/j.bmc.2011.04.033

upstream raw materials:

3,5-bis(4-chlorobenzylidene)-1-methylpiperidin-4-one

malononitrile

Downstream raw materials:

4-(4-chlorophenyl)-8-[(E)-(4-chlorophenyl)-methylidene]-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-6-methyl-5,6,7,8-tetrahydro-4H-pyrano[3,2-c]pyridin-2-ylamine