Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

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Chemical Name:Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate
CAS No.:122900-37-2
Molecular Formula:C₃₅H₄₃N₄O₉P*2K
Molecular Weight:772.918
Hs Code.:

Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

Synonyms:Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

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Chemical Property of Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

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Technology Process of Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

There total 4 articles about Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 122900-11-2
N-(diethylphosphoryl)-L-isoleucyl-O-<<(N,N-dibenzylamino)carbonyl>methyl>-L-tyrosylglycine methyl ester

: 122900-37-2
Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

Guidance literature:: With potassium hydroxide; In ethanol; for 24h;
DOI:10.1021/jm00163a044

Reference yield:

: 122900-74-7
(2S,3S)-2-(Diethoxy-phosphorylamino)-3-methyl-pentanoic acid benzyl ester

: 122900-37-2
Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

2: 86 percent / DCC / dimethylformamide / 0 °C

3: 37 percent / aq. KOH / ethanol / 24 h

With potassium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a044

Reference yield:

: 122899-90-5
N-(diethylphosphoryl)-L-isoleucine

: 122900-37-2
Potassium; {(S)-3-{4-[(dibenzylcarbamoyl)-methoxy]-phenyl}-2-[(2S,3S)-2-(ethoxy-hydroxy-phosphorylamino)-3-methyl-pentanoylamino]-propionylamino}-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / DCC / dimethylformamide / 0 °C

2: 37 percent / aq. KOH / ethanol / 24 h

With potassium hydroxide; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a044