4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

Base Information

Chemical Name:4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate
CAS No.:932016-08-5
Molecular Formula:C₂HF₃O₂*C₁₅H₁₁BrFN₃O₂
Molecular Weight:478.198
Hs Code.:

Synonyms:4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

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Chemical Property of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

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Technology Process of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

There total 2 articles about 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 76-05-1
trifluoroacetic acid

: 932016-08-5
4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

Guidance literature:: 4-bromo-2-fluoroaniline; 7-benzyloxy-4-chloro-6-methoxyquinazoline; In toluene; at 73 ℃; for 4h;

trifluoroacetic acid; In toluene; at 73 ℃; for 6h;

With water; In toluene; at 60 - 70 ℃; for 22.5h; Product distribution / selectivity;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 76-05-1
trifluoroacetic acid

: 162364-72-9
7-benzyloxy-4-chloro-6-methoxyquinazoline

: 932016-08-5
4-(4-bromo-2-fluoroanilino)-6-methoxy-7-hydroxyquinazoline trifluoroacetate

Guidance literature:: 4-bromo-2-fluoroaniline; trifluoroacetic acid; 7-benzyloxy-4-chloro-6-methoxyquinazoline; In toluene; at 73 ℃; for 5.16667h;

With water; In toluene; at 60 - 68 ℃; for 8.25h; Product distribution / selectivity;